NEUROMYELITIS OPTICA SPECTRUM DISORDER (NMOSD) DENGAN ANTIBODI AQP4 POSITIF

Background: Neuromyelitis optica (NMO) is an in?ammatory demyelinating autoimmune disease of the central nervous system that most commonly affects optic nerves and spinal cord. Seropositive antiAQP4 differentiates NMO from MS presence manifestation in postrema, brainsteam or diencephalic areas extend to Spectrum Disorder (NMOSD). Case Description: A 18 years old male complain sudden vision loss on his left eye since 2 weeks ago. The examination show visual acuity right was 6/6 LPBP eye. Positive RAPD eye, funduscopy OCT RNFL within normal limits. Head MRI focus orbita with contrast neuritis. Patient diagnosed retrobulbar neuritis ONTT therapy given. improved 1/60 then change oral steroid. Four months later, patient suddenly got accompanied by paraparesis. NLP 1/300, mid-dilated papil. results edema papil atrophy An head orbital whole spain reexamined followed VEP AntiAQP4 which showed NMOSD. He given continued immunosuppressants. 3/60 remained 1/300. Discussion: This first presented clinical supporting symptoms suggesting a new attack paraparesis feature supported seropositive AQP4 indicates Conclusion: Establishment diagnosis administration quickly precisely can reduce severity risk recurrence leads greater disability blindness. Key Words: Optica, Optica Disorder,